Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.
Identifieur interne : 002301 ( Main/Exploration ); précédent : 002300; suivant : 002302Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.
Auteurs : Edwige Roy [Australie] ; Zoltan Neufeld [Australie] ; Luca Cerone [Australie] ; Ho Yi Wong [Australie] ; Samantha Hodgson [Australie] ; Jean Livet [France] ; Kiarash Khosrotehrani [Australie]Source :
- The EMBO journal [ 1460-2075 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Follicule pileux, Peau, Épiderme.
- physiologie : Cellules souches, Kératinocytes.
- Analyse spatio-temporelle, Animaux, Différenciation cellulaire, Modèles théoriques, Prolifération cellulaire, Souris, Techniques cytologiques.
English descriptors
- KwdEn :
- MESH :
- cytology : Epidermis, Hair Follicle, Skin.
- physiology : Keratinocytes, Stem Cells.
- Animals, Cell Differentiation, Cell Proliferation, Cytological Techniques, Mice, Models, Theoretical, Spatio-Temporal Analysis.
Abstract
Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.
DOI: 10.15252/embj.201693806
PubMed: 27797819
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Differentiation</term>
<term>Cell Proliferation</term>
<term>Cytological Techniques</term>
<term>Epidermis (cytology)</term>
<term>Hair Follicle (cytology)</term>
<term>Keratinocytes (physiology)</term>
<term>Mice</term>
<term>Models, Theoretical</term>
<term>Skin (cytology)</term>
<term>Spatio-Temporal Analysis</term>
<term>Stem Cells (physiology)</term>
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<term>Animaux</term>
<term>Cellules souches (physiologie)</term>
<term>Différenciation cellulaire</term>
<term>Follicule pileux (cytologie)</term>
<term>Kératinocytes (physiologie)</term>
<term>Modèles théoriques</term>
<term>Peau (cytologie)</term>
<term>Prolifération cellulaire</term>
<term>Souris</term>
<term>Techniques cytologiques</term>
<term>Épiderme (cytologie)</term>
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<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Follicule pileux</term>
<term>Peau</term>
<term>Épiderme</term>
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<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Epidermis</term>
<term>Hair Follicle</term>
<term>Skin</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules souches</term>
<term>Kératinocytes</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Keratinocytes</term>
<term>Stem Cells</term>
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<term>Cytological Techniques</term>
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<term>Différenciation cellulaire</term>
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<term>Prolifération cellulaire</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en">Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.</div>
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